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Paraquat Statistics

Paraquat Statistics - Herbicide From Zeneca

A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the
University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was
provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. 
EXTOXNET primary files maintained and archived at Oregon State University
Revised June 1996

Trade and Other Names: Product names include Crisquat, Cyclone, Dextrone, Dexuron, Gramoxone Extra, Herbaxone, Ortho Weed and Spot
Killer, and Sweep. The compound may be found in formulations with many other herbicides, including simazine and diquat dibromide. 
Regulatory Status: Paraquat is a highly toxic compound in EPA toxicity class I. Products containing it must be is labeled with the Signal Words
DANGER - POISON. Paraquat is a Restricted Use Pesticide (RUP). RUPs may be purchased and used only by certified applicators.
Chemical Class: quaternary nitrogen compound
Introduction: Paraquat is a quaternary nitrogen herbicide widely used for broadleaf weed control. It is a quick-acting, nonselective compound, that
destroys green plant tissue on contact and by translocation within the plant. It has been employed for killing marijuana in the U.S. and in Mexico.
It is also used as a crop desiccant and defoliant, and as an aquatic herbicide.
Formulation: Not Available 
Toxicological Effects:
Acute toxicity: Paraquat is highly toxic via ingestion, with reported oral LD50 values of 110 to 150 mg/kg in rats, 50 mg/kg in monkeys, 48 mg/kg in cats, and 50 to 70 mg/kg in cows [8,87]. The toxic effects of paraquat are due to the cation, and the halogen anions have little toxic effects [87]. The dermal LD50 in rabbits is 236 to 325 mg/kg, indicating moderate toxicity by this route [58,87].
The 4-hour inhalation LC50 is greater than 20 mg/L for the technical grade of the compound [87]. It causes skin and eye irritation in rabbits (severe for some of the formulated products) and also has caused skin sensitization in guinea pigs in some formulations [87].
Effects due to high acute exposure to paraquat may include excitability and lung congestion, which in some cases leads to convulsions, incoordination, and death by respiratory failure [87]. If swallowed, burning of the mouth and throat often occurs, followed by
gastrointestinal tract irritation, resulting in abdominal pain, loss of appetite, nausea, vomiting, and diarrhea [8]. Other toxic effects include thirst, shortness of breath, rapid heart rate, kidney failure, lung sores, and liver injury [32]. Some symptoms may not occur until days after exposure. Persons with lung problems may be at increased risk from exposure. Many cases of illness and/or death have been
reported in humans. The estimated lethal dose (via ingestion) for paraquat in humans is 35 mg/kg [8]. A maximum of 3.5 mg/hour could be absorbed through the dermal or respiratory route without damage [32]. 
Chronic toxicity: As indicated above, repeated exposures may cause skin irritation, sensitization, or ulcerations on contact [58,87]. In animal studies, rats showed no effects after being exposed for 2 years to paraquat at doses of 1.25 mg/kg/day [8]. Dogs, however, developed lung problems after being exposed for 2 years at high doses (above 34 mg/kg/day) [8]. In a study of 30 workers spraying
paraquat over a 12-week period, approximately one-half had minor irritation of the eyes and nose [8]. Of 296 spray operators with gross and prolonged skin exposure, 55 had damaged fingernails as indicated by discoloration, nail deformities, or loss of nails [8]. 
Reproductive effects: In a long-term rat study at doses up to 5 mg/kg/day, no adverse reproductive effects were reported [111].
However, paraquat dichloride injected intraperitoneally at 3 mg/kg/day on days 8 to 16 of gestation increased fetal mortality in rats [8].
Hens given high levels of paraquat in their drinking water for 14 days produced an increased percentage of abnormal eggs [8]. It is unlikely to cause reproductive effects in humans at expected exposure levels. 
Teratogenic effects: Offspring of mice dosed with high doses of paraquat during the organ-forming period of pregnancy had less complete bone development than the mice given lower doses [111]. Offspring of rats given similar treatment showed no developmental defects at any dose, but fetal and maternal body weights were lower than normal [111]. Other studies of paraquat using rabbits and mice
have shown no teratogenic effects [8]. The weight of evidence suggests that paraquat does not cause birth defects at doses which might reasonably be encountered. 
Mutagenic effects: Paraquat has been shown to be mutagenic in microorganism tests and mouse cell assays [8]. It was unclear what levels of exposure are necessary to produce these effects. 
Carcinogenic effects: Mice fed paraquat dichloride for 99 weeks at high levels did not show cancerous growths [112]. Rats fed high doses for 113 (male) or 124 weeks (female) developed lung, thyroid, skin, and adrenal tumors [111]. Thus, the evidence regarding carcinogenic effects of paraquat is inconclusive. 
Organ toxicity: Paraquat affects the lungs, heart, liver, kidneys, cornea, adrenal glands, skin, and digestive system. 
Fate in humans and animals: Paraquat is not readily absorbed from the stomach, and is even more slowly absorbed across the skin.
Oral doses of paraquat in rats are excreted mainly in the feces, while paraquat injected into the abdomen leaves through urine [8]. In the stomach and gastrointestinal tract, paraquat metabolites may be more readily absorbed than the parent compound, but their identities and toxicities are unknown [111]. Paraquat may concentrate in lung tissue, where it can be transformed to highly reactive and potentially toxic forms [87]. In one study, farm animals excreted over 90% of the administered paraquat within a few days. It was slightly absorbed and metabolized in the gastrointestinal tract. Milk and eggs contained small amounts of two paraquat metabolites [58]. 
Ecological Effects:
Effects on birds: The compound is moderately toxic to birds, with reported acute oral LD50 values of 981 mg/kg and 970 mg/kg in bobwhite and Japanese quail, respectively [58]. The reported 5- to 8-day dietary LC50 value for the compound is 4048 ppm in mallards
Effects on aquatic organisms: Paraquat is slightly to moderately toxic to many species of aquatic life, including rainbow trout, bluegill, and channel catfish [58,8]. The reported 96-hour LC50 for paraquat is 32 mg/L in rainbow trout, and 13 mg/L in brown trout
[58]. The LC50 for the aquatic invertebrate Daphnia pulex is 1.2 to 4.0 mg/L [8]. In rainbow trout exposed for 7 days to paraquat, the chemical was detected in the gut and liver, but not in the meat of the fish. Aquatic weeds may bioaccumulate the compound. In one study, 4 days after paraquat was applied as an aquatic herbicide, weeds sampled showed significant residue levels [87]. At high levels, paraquat inhibits the photosynthesis of some algae in stream waters [87]. 
Effects on other organisms: Paraquat is nontoxic to honey bees [112]. 
Environmental Fate: 
Breakdown in soil and groundwater: Paraquat is highly persistent in the soil environment, with reported field half-lives of greater than 1000 days [11,58]. The reported half-life for paraquat in one study ranged from 16 months (aerobic laboratory conditions) to 13 years (field study) [113]. Ultraviolet light, sunlight, and soil microorganisms can degrade paraquat to products which are less toxic than
the parent compound. The strong affinity for adsorption by soil particles and organic matter may limit the bioavailability of paraquat to plants, earthworms, and microorganisms [11,58]. The bound residues may persist indefinitely and can be transported in runoff with the
sediment. Paraquat is not significantly mobile in most soils [8]. That which does not become associated with soil particles can be decomposed to a nontoxic end product by soil bacteria [32]. Thus, paraquat does not present a high risk of groundwater contamination.
Of 721 groundwater samples analyzed, only one contained paraquat, at a concentration of 20 mg/L [111]. 
Breakdown in water: Paraquat will be bound to suspended or precipitated sediment in the aquatic environment, and may be even more highly persistent than on land due to limited availability of oxygen. It had a half-life in a laboratory stream water column of 13.1 hours
[114]. In another study, paraquat dichloride was stable for up to 30 days [111]. In a third study of low levels in water, paraquat had a half-life of 23 weeks [111]. 
Breakdown in vegetation: Paraquat dichloride droplets decompose when exposed to light after being applied to maize, tomato, and broad-bean plants. Small amounts of residues were found in potatoes treated with paraquat as a desiccant, and boiling the potatoes did not
reduce the residue [8]. 
Physical Properties: 
Appearance: Paraquat salts are colorless, white, or pale yellow crystalline solids, which are hygroscopic and odorless [1]. 
Chemical Name: 1,1'-dimethyl-4,4'-bipyridinium [1] 
CAS Number: 1910-42-5 
Molecular Weight: 257.20 
Water Solubility: 700,000 mg/L @ 20 C [1] 
Solubility in Other Solvents: Dichloride salt is sparingly soluble in lower alcohols [1] 
Melting Point: Decomposes @ 300 C [1] 
Vapor Pressure: Negligible @ room temperature (paraquat dichloride) [1] 
Partition Coefficient: 4.4683 [58] 
AdsorptionCoefficient: 1,000,000 (estimated) [11] 

Exposure Guidelines:
ADI: 0.004 mg/kg/day [12] 
MCL: Not Available 
RfD: 0.0045 mg/kg/day [13] 
PEL: Not Available 
HA: 0.03 mg/L (lifetime) [111] 
TLV: 0.1 mg/m3 (8-hour) (respirable fraction) [17] 

Basic Manufacturer:

Zeneca Ag Products 
1800 Concord Pike
Wilmington, DE 19897

Phone: 800-759-4500 
Emergency: 800-759-2500 

References for the information in this PIP can be found in Reference List Number 10 

DISCLAIMER: The information in this profile does not in any way replace or supersede the information on the pesticide product labeling or
other regulatory requirements. Please refer to the pesticide product labeling. 

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Dec 1997 15:40:44 

                                    DERMAL TOXICITY OF PARAQUAT
    Sabina Luty, Jadwiga Latuszynska, Janina Halliop, Alina Tochman, Daniela Obuchowska, Barbara Korczak, Ewa
                                           Przylepa, Edmund Bychawski 
Department of Pathomorphology, Institute of Agricultural Medicine, Lublin, Poland 
Citation: Luty S, Latuszynska J, Halliop J, Tochman A, Obuchowska D, Korczak B, Przylepa E, Bychawski E: Dermal toxicity of paraquat.
Ann Agric Environ Med 1997, 4, 217-227. 
Abstract: Dermal toxicity of paraquat in rats was studied, as well as its influence on internal organs, phagocytic and bactericidal activity of the
neutrophile system, and the behaviour of the rats. The studies were conducted on 30 female rats of Wistar strain. The animals were divided into
three groups, of which two groups were experimentally exposed to dermal absorption of paraquat (1/2 LD50 or 1/10 LD50), and one group was
exposed as a control to dermal absorption of the solvent. The animals were exposed to dermal absorption for 4 hours daily for a period of 4
weeks. After 28 days, the rats were anaesthetized and blood was drawn from the heart to evaluate the activity of the neutrophilic system while the
internal organs were excised for histological and ultrastructural studies. Histological and ultrastructural changes were observed in the lung,
manifested by widened interalveolar septa filled with erythrocytes, lymphocytes, plasmatic cells, or alveolar macrophages. In the interalveolar
septa bunches of collagen fibres were noted, while in the lumen of alveoli exudate and erythrocytes were observed. Histological and ultrastructural
changes were also noted in the heart. They manifested themselves by focal hypertrophy of the interstitial tissue and by the increase of collagen
fibres in bunches between cardiomyocytes. Less severe pathological changes were observed in kidney and liver. In the brain histological changes
occurred in the neutrocytes. The bactericidal activity of the neutrophilic system increased in both experimental groups. Stimulation of phagocytosis
was noted only in animals exposed to 1/10 LD50 - the lower dose of paraquat. The cognitive activity increased in both experimental groups after
2-weeks exposure to dermally applied paraquat, but returned to normal 2 weeks later. 
Address for correspondence: Professor Sabina Luty, PhD, Head, Department of Pathomorphology, Institute of Agricultural Medicine,
P.O.Box 185, 20-950 Lublin, Poland. 
Key words: dermal toxicity, paraquat, histopathology, ultrastructure, neutrophile activity, behaviour.

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